- Lycorine-type alkaloid from the Amaryllidaceae plant family
- Lycorine exhibits cytostatic effects by targeting the actin cytoskeleton rather than by inducing apoptosis in cancer cells, though lycorine was found to cause apoptosis at different stages in a cell cycle
- White amorphous solid
- For research use only. Not for human or veterinary use.
Source: Narcissus poeticus recurvus
Purity: ≥98 %
Pricing for academic institutions*:
- 5 mg – 363 CZK
- 10 mg – 545 CZK
- 50 mg – 1815 CZK
- 100 mg – 2723 CZK
Other quantities on request.
*Registration required to use the discount.
YUAN, Q., ZHANG, X., WEI, W., et al. Lycorine improves peripheral nerve function by promoting Schwann cell autophagy via AMPK pathway activation and MMP9 downregulation in diabetic peripheral neuropathy. Pharmacological Research 2022, 175. DOI: 10.1016/j.phrs.2021.105985
NAIR, J. J., VAN STADEN, J. Cytotoxicity Studies of Lycorine Alkaloids of the Amaryllidaceae. Natural Product Communications 2014, 9(8). DOI: 10.1177/1934578×1400900834
ROY, M., LIANG, L., XIAO, X., FENG, P., YE, M., LIU, J. Lycorine: A prospective natural lead for anticancer drug discovery. Biomedicine & Pharmacotherapy 2018, 107, 615-624. DOI: 10.1016/j.biopha.2018.07.147
LAMORAL-THEYS, D., ANDOLFI, A., VAN GOIETSENOVEN, G., et al. Lycorine, the Main Phenanthridine Amaryllidaceae Alkaloid, Exhibits Significant Antitumor Activity in Cancer Cells That Display Resistance to Proapoptotic Stimuli: An Investigation of Structure−Activity Relationship and Mechanistic Insight. Journal of Medicinal Chemistry 2009, 52(20), 6244-6256. DOI: 10.1021/jm901031h
WU, S., QIU, Y., SHAO, Y., et al. Lycorine Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3. Frontiers in Pharmacology 2018, 9. DOI: 10.3389/fphar.2018.00881